Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome.
نویسندگان
چکیده
OBJECTIVE There is a need for a simple and accurate method for the assessment of cardiovascular risk in polycystic ovary syndrome (PCOS). Lipid accumulation product (LAP) is based on the assessment of waist circumference and serum triglycerides that yield an estimation of lipid overaccumulation. We aimed to determine whether LAP is associated with metabolic syndrome (MetS) in Caucasian women with PCOS. DESIGN We studied 222 women with PCOS who were diagnosed using the Rotterdam criteria. In all the subjects and controls, LAP was determined and the MetS was assessed using three different international criteria, NCEP-ATP III, IDF, and JIS. ROC curve and logistic regression analyses were performed to determine and analyze associations with the MetS. RESULTS In the study population the prevalence of MetS was 16.2-19.4%. The cut-off value of 25.9 determined that LAP has the strongest association with MetS whichever international criteria are used, followed by HDL (NCEP-ATP III and JIS) and glucose (IDF). CONCLUSIONS LAP is used as an independent clinical indicator for MetS in our PCOS women of Caucasian origin. The high diagnostic accuracy of LAP is superseding the need for the use of multiple clinical indicators for the assessment of lipid accumulation as a prerequisite for diagnosis of metabolic and cardiovascular diseases in PCOS women.
منابع مشابه
Pmn-15: The Role of Lifestyle Modification in Management of Overweight Infertile Women with Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome (PCOS) is a complex, heterogeneous disorder of uncertain etiology, with a prevalence of up to 10% and frequently associated with obesity, with at least 50% of women with polycystic ovary syndrome demonstrating overweight or obesity defined by body mass index >25 or >30 kg/m2. The syndrome is associated with numerous morbidities, including infertility, obste...
متن کاملMetabolic and Endocrine Characteristics of Indian Women with Polycystic Ovary Syndrome
Objective Polycystic ovary syndrome (PCOS) is one of the most common endocrinological disorders among women of reproductive age and the leading cause of female infertility. This study intends to evaluate the lipid profile, hormonal levels [free T3 (fT3), free T4 (fT4), thyroid stimulating hormone (TSH), insulin, luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin] in PCO...
متن کاملEffect of aerobic training in women with polycystic ovary syndrome
Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age and is associated with various metabolic perturbations. Chronic low grade inflammation has been reported to participate in the pathogenesis of metabolic syndrome. In this study we examined the effects of 8 weeks aerobic training on serum C-reactive protein level and cardiometab...
متن کاملMetabolic Syndrome and Its Characteristics among Reproductive-Aged Women with Polycystic Ovary Syndrome: A Cross-sectional Study in Northwest Iran
متن کامل
Pnm-5: Midwifery Intensive Cares in Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome is a common endocrine disorder with 3-7% prevalence in the general population and 10% in women of childbearing. This rate has increased in infertile women. The main composition of this syndrome includes anovulation or olygoovulation, clinical and laboratory signs of increased androgens and observation polycystic ovaries on ultrasound in evaluation. In this ...
متن کاملComparison of the Effects of Combined Oral Contraceptives Containing Progestins with Low Androgenic and Anti-androgenic Activities on the Clinical, Androgenic, and Metabolic Manifestations of Polycystic Ovary Syndrome
Introduction: Combined oral contraceptives (COCs) are commonly considered as the first-line treatment for polycystic ovary syndrome (PCOS). This study aimed to compare the effects of COCs with respect to their progestin component on the clinical, hormonal, and metabolic outcomes of women with PCOS. Data were extracted by searching PubMed, Scopus, EMBASE, and Google Scholar, without any time lim...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Hormones
دوره 15 1 شماره
صفحات -
تاریخ انتشار 2016